My Diabetes Information Blogs
More Evidence of Heart Harm from Thiazolidinedione Diabetes Medication
12/19/07
Type II Diabetes
Another study has revealed substantial heart risks among thiazolidinedione users—especially among older adults.
Authors of the new study published this week in JAMA suggest that these results provide further evidence that thiazolidinediones (TZDs) may cause more harm than good. The dangers are more than just concerns over congestive heart failure (CHF).
“Our findings argue against current labeling of TZDs that warns against use only in persons at high risk of CHF, as we did not identify any subgroup of older diabetes patients who may be protected from adverse effects of TZDs,” they write.“
The JAMA study focused on mature patients in their retirement years. Compared to other oral anti-diabetes medicine combination users, users of TZD monotherapy had:
- A 60 percent increased risk of congestive heart failure.
- A 40 percent increased risk of heart attack.
- A 29 percent increased risk of death.
These increased risks associated with TZD use appeared limited to rosiglitazone.
If you are in your 30s or 40s, TZDs may still be a reasonable choice for you. You and your doctor may determine that your heart health is excellent, and glucose management thiazolidinediones provide now will ensure that your heart stays healthy in the future. Perhaps later you will use insulin and other medications.
My Diabetes Information applauds the work that researchers have done to identify possible harm from certain drugs. Nevertheless, for you as in individual your doctor may be willing to go against the general recommendations to address your particular circumstance.
Source:
JAMA, December 2007