Diabetes Treatment More Complex, Costly

11/12/08 General

A progressively more complex and expensive array of treatments for type 2 diabetes is being prescribed to an increasing number of adults, according to a report in Archives of Internal Medicine, one of the JAMA/Archives journals.

In 2000, more than 11 million Americans had been diagnosed with diabetes, according to background information in the article. "By 2050, the number of Americans with diabetes is expected to soar to 29 million, a prevalence of 7 percent," the authors write. "The annual economic burden of diabetes is estimated at $132 billion and increasing. In 2002, more than one-tenth of U.S. health care expenditures were attributable to diabetes."

As costs and prevalence increase, managing diabetes also has become increasingly complex, as physicians prescribe more medications to each patient and combine drugs from different therapeutic classes.

To evaluate these trends, G. Caleb Alexander, M.D., M.S., of the University of Chicago Hospitals, and colleagues gathered diabetes prescription information and costs from national databases. The researchers analyzed prescription data from U.S. patients age 35 and older with type 2 diabetes who visited a physician's office between 1994 and 2007. Information about medication costs was available from 2001 to 2007.

The analysis revealed that, between 1994 and 2007:

• The estimated number of yearly patient visits to treat diabetes increased from 25 million to 36 million
• The average number of medications prescribed per treated patient increased from 1.14 to 1.63
• Among visits in which any treatment was given, the number in which only one drug was prescribed decreased from 82 percent to 47 percent
• Insulin use decreased from 38 percent in 1994 to a low of 25 percent in 2000, and then increased again to 28 percent
• The types of medications prescribed shifted—the use of sulfonylurea drugs decreased from 67 percent to 34 percent of treatment visits, while use of newer drugs such as biguanides and glitazones (drugs that decrease glucose production in the liver and increase the body’s ability to effectively use insulin) increased, so that by 2007 these agents were prescribed at 54 percent and 28 percent of treatment visits, respectively

The increasing use of glitazones—along with other new treatments, including new forms of insulin and other new classes of drugs—accounted for increases in average cost per prescription (from $56 in 2001 to $76 in 2007) and in overall medication expenditures for those with diabetes (from $6.7 billion in 2001 to $12.5 billion in 2007).

"We document large shifts in patterns of diabetes treatment and pharmaceutical expenditures across treatment classes," the authors conclude. "Whether increased treatment costs are balanced by improved outcomes associated with these changes cannot be evaluated in the absence of data comparing effectiveness and cost-effectiveness across treatment classes.”

Researchers suggest determining that cost-effectiveness by looking at outcomes like maximizing glycemic control and minimizing diabetes-related death. 

Source:

JAMA